	   SnapGene      [gacggatcgggagatctcccgatcccctatggtgcactctcagtacaatctgctctgatgccgcatagttaagccagtatctgctccctgcttgtgtgttggaggtcgctgagtagtgcgcgagcaaaatttaagctacaacaaggcaaggcttgaccgacaattgcatgaagaatctgcttagggttaggcgttttgcgctgcttcgcgatgtacgggccagatatacgcgttgacattgattattgactagttattaatagtaatcaattacggggtcattagttcatagcccatatatggagttccgcgttacataacttacggtaaatggcccgcctggctgaccgcccaacgacccccgcccattgacgtcaataatgacgtatgttcccatagtaacgccaatagggactttccattgacgtcaatgggtggagtatttacggtaaactgcccacttggcagtacatcaagtgtatcatatgccaagtacgccccctattgacgtcaatgacggtaaatggcccgcctggcattatgcccagtacatgaccttatgggactttcctacttggcagtacatctacgtattagtcatcgctattaccatggtgatgcggttttggcagtacatcaatgggcgtggatagcggtttgactcacggggatttccaagtctccaccccattgacgtcaatgggagtttgttttggcaccaaaatcaacgggactttccaaaatgtcgtaacaactccgccccattgacgcaaatgggcggtaggcgtgtacggtgggaggtctatataagcagagctctctggctaactagagaacccactgcttactggcttatcgaaattaatacgactcactatagggagacccaagctggctagcgtttaaagccactgggatccgccaccatggaagattcgatggacatggacatgagccccctgaggccccagaactatcttttcggttgtgaactaaaggccgacaaagattatcactttaaggtggataatgatgaaaatgagcaccagttatctttaagaacggtcagtttaggggctggtgcaaaggatgagttgcacattgttgaagcagaggcaatgaattacgaaggcagtccaattaaagtaacactggcaactttgaaaatgtctgtacagccaacggtttcccttgggggctttgaaataacaccaccagtggtcttaaggttgaagtgtggttcagggccagtgcatattagtggacagcacttagtagctgtggaggaagatgcagagtcagaagatgaagaggaggaggatgtgaaactcttaagtatatctggaaagcggtctgcccctggaggtggtagcaaggttccacagaaaaaagtaaaacttgctgctgatgaagatgatgacgatgatgatgaagaggatgatgatgaagatgatgatgatgatgattttgatgatgaggaagctgaagaaaaagcgccagtgaagaaatctatacgagatactccagccaaaaatgcacaaaagtcaaatcagaatggaaaagactcaaaaccatcatcaacaccaagatcaaaaggacaagaatccttcaagaaacaggaaaaaactcctaaaacaccaaaaggacctagttctgtagaagacattaaagcaaaaatgcaagcaagtatagaaaaaggtggttctcttcccaaagtggaagccaaattcatcaattatgtgaagaattgcttccggatgactgaccaagaggctattcaagatctctggcagtggaggaagtctcttctcgagggcggtggaggaagcggcggaggtggatctatggtgagcaagggcgaggagctgttcaccggggtggtgcccatcctggtcgagctggacggcgacgtaaacggccacaagttcagcgtgtccggcgagggcgagggcgatgccacctacggcaagctgaccctgaagttcatctgcaccaccggcaagctgcccgtgccctggcccaccctcgtgaccaccctgacctacggcgtgcagtgcttcagccgctaccccgaccacatgaagcagcacgacttcttcaagtccgccatgcccgaaggctacgtccaggagcgcaccatcttcttcaaggacgacggcaactacaagacccgcgccgaggtgaagttcgagggcgacaccctggtgaaccgcatcgagctgaagggcatcgacttcaaggaggacggcaacatcctggggcacaagctggagtacaactacaacagccacaacgtctatatcatggccgacaagcagaagaacggcatcaaggtgaacttcaagatccgccacaacatcgaggacggcagcgtgcagctcgccgaccactaccagcagaacacccccatcggcgacggccccgtgctgctgcccgacaaccactacctgagcacccagtccgccctgagcaaagaccccaacgagaagcgcgatcacatggtcctgctggagttcgtgaccgccgccgggatcactctcggcatggacgagctgtacaagtagtctagagggcccgtttaaacccgctgatcagcctcgactgtgccttctagttgccagccatctgttgtttgcccctcccccgtgccttccttgaccctggaaggtgccactcccactgtcctttcctaataaaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctggggggtggggtggggcaggacagcaagggggaggattgggaagacaatagcaggcatgctggggatgcggtgggctctatggcttctgaggcggaaagaaccagctggggctctagggggtatccccacgcgccctgtagcggcgcattaagcgcggcgggtgtggtggttacgcgcagcgtgaccgctacacttgccagcgccctagcgcccgctcctttcgctttcttcccttcctttctcgccacgttcgccggctttccccgtcaagctctaaatcgggggctccctttagggttccgatttagtgctttacggcacctcgaccccaaaaaacttgattagggtgatggttcacgtagtgggccatcgccctgatagacggtttttcgccctttgacgttggagtccacgttctttaatagtggactcttgttccaaactggaacaacactcaaccctatctcggtctattcttttgatttataagggattttgccgatttcggcctattggttaaaaaatgagctgatttaacaaaaatttaacgcgaattaattctgtggaatgtgtgtcagttagggtgtggaaagtccccaggctccccagcaggcagaagtatgcaaagcatgcatctcaattagtcagcaaccaggtgtggaaagtccccaggctccccagcaggcagaagtatgcaaagcatgcatctcaattagtcagcaaccatagtcccgcccctaactccgcccatcccgcccctaactccgcccagttccgcccattctccgccccatggctgactaattttttttatttatgcagaggccgaggccgcctctgcctctgagctattccagaagtagtgaggaggcttttttggaggcctaggcttttgcaaaaagctcccgggagcttgtatatccattttcggatctgatcaagagacaggatgaggatcgtttcgcatgattgaacaagatggattgcacgcaggttctccggccgcttgggtggagaggctattcggctatgactgggcacaacagacaatcggctgctctgatgccgccgtgttccggctgtcagcgcaggggcgcccggttctttttgtcaagaccgacctgtccggtgccctgaatgaactgcaggacgaggcagcgcggctatcgtggctggccacgacgggcgttccttgcgcagctgtgctcgacgttgtcactgaagcgggaagggactggctgctattgggcgaagtgccggggcaggatctcctgtcatctcaccttgctcctgccgagaaagtatccatcatggctgatgcaatgcggcggctgcatacgcttgatccggctacctgcccattcgaccaccaagcgaaacatcgcatcgagcgagcacgtactcggatggaagccggtcttgtcgatcaggatgatctggacgaagagcatcaggggctcgcgccagccgaactgttcgccaggctcaaggcgcgcatgcccgacggcgaggatctcgtcgtgacccatggcgatgcctgcttgccgaatatcatggtggaaaatggccgcttttctggattcatcgactgtggccggctgggtgtggcggaccgctatcaggacatagcgttggctacccgtgatattgctgaagagcttggcggcgaatgggctgaccgcttcctcgtgctttacggtatcgccgctcccgattcgcagcgcatcgccttctatcgccttcttgacgagttcttctgagcgggactctggggttcgaaatgaccgaccaagcgacgcccaacctgccatcacgagatttcgattccaccgccgccttctatgaaaggttgggcttcggaatcgttttccgggacgccggctggatgatcctccagcgcggggatctcatgctggagttcttcgcccaccccaacttgtttattgcagcttataatggttacaaataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgcattctagttgtggtttgtccaaactcatcaatgtatcttatcatgtctgtataccgtcgacctctagctagagcttggcgtaatcatggtcatagctgtttcctgtgtgaaattgttatccgctcacaattccacacaacatacgagccggaagcataaagtgtaaagcctggggtgcctaatgagtgagctaactcacattaattgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgccagctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtattgggcgctcttccgcttcctcgctcactgactcgctgcgctcggtcgttcggctgcggcgagcggtatcagctcactcaaaggcggtaatacggttatccacagaatcaggggataacgcaggaaagaacatgtgagcaaaaggccagcaaaaggccaggaaccgtaaaaaggccgcgttgctggcgtttttccataggctccgcccccctgacgagcatcacaaaaatcgacgctcaagtcagaggtggcgaaacccgacaggactataaagataccaggcgtttccccctggaagctccctcgtgcgctctcctgttccgaccctgccgcttaccggatacctgtccgcctttctcccttcgggaagcgtggcgctttctcatagctcacgctgtaggtatctcagttcggtgtaggtcgttcgctccaagctgggctgtgtgcacgaaccccccgttcagcccgaccgctgcgccttatccggtaactatcgtcttgagtccaacccggtaagacacgacttatcgccactggcagcagccactggtaacaggattagcagagcgaggtatgtaggcggtgctacagagttcttgaagtggtggcctaactacggctacactagaagaacagtatttggtatctgcgctctgctgaagccagttaccttcggaaaaagagttggtagctcttgatccggcaaacaaaccaccgctggtagcggtttttttgtttgcaagcagcagattacgcgcagaaaaaaaggatctcaagaagatcctttgatcttttctacggggtctgacgctcagtggaacgaaaactcacgttaagggattttggtcatgagattatcaaaaaggatcttcacctagatccttttaaattaaaaatgaagttttaaatcaatctaaagtatatatgagtaaacttggtctgacagttaccaatgcttaatcagtgaggcacctatctcagcgatctgtctatttcgttcatccatagttgcctgactccccgtcgtgtagataactacgatacgggagggcttaccatctggccccagtgctgcaatgataccgcgagacccacgctcaccggctccagatttatcagcaataaaccagccagccggaagggccgagcgcagaagtggtcctgcaactttatccgcctccatccagtctattaattgttgccgggaagctagagtaagtagttcgccagttaatagtttgcgcaacgttgttgccattgctacaggcatcgtggtgtcacgctcgtcgtttggtatggcttcattcagctccggttcccaacgatcaaggcgagttacatgatcccccatgttgtgcaaaaaagcggttagctccttcggtcctccgatcgttgtcagaagtaagttggccgcagtgttatcactcatggttatggcagcactgcataattctcttactgtcatgccatccgtaagatgcttttctgtgactggtgagtactcaaccaagtcattctgagaatagtgtatgcggcgaccgagttgctcttgcccggcgtcaatacgggataataccgcgccacatagcagaactttaaaagtgctcatcattggaaaacgttcttcggggcgaaaactctcaaggatcttaccgctgttgagatccagttcgatgtaacccactcgtgcacccaactgatcttcagcatcttttactttcaccagcgtttctgggtgagcaaaaacaggaaggcaaaatgccgcaaaaaagggaataagggcgacacggaaatgttgaatactcatactcttcctttttcaatattattgaagcatttatcagggttattgtctcatgagcggatacatatttgaatgtatttagaaaaataaacaaataggggttccgcgcacatttccccgaaaagtgccacctgacgtc  <·            !      #   "      &            *   !   +      )            3   "         '         "               &                                 &                        "   )   $          1      "   (   !   '      ,      %      %      "               !      !   *   #      $   '   #   (   *   F   "      "                        !   /                                    &   $                                                          (       %      $   $   $                          '                                    !         	                                    )   !         "   $                  &         "                                   '                   
               #   1            *   *   &                  (               *   %      #                     #   "                          2   '         #   #               '      +         š1©ªRÑ·
¸
¹
¾
Ã
Ò
Ó
ô
"+,ÐÑú¢e¢$B¯1â0  š1›½Ùo‘à	Ô
Ý
õ
¡C�†š%‚°2/×vá® · °Sº
¿
-VÞý¨ø£Cãˆö1! Ø �2«Ü?–œ�°Ò

Ä
ÿ
#Ò#ÃûW–£f?óÅwÛ7¶ 	 d -´¾p #Q(EP¿ÝÍ	Õ
L&D¬2±Ø#  ?ÅRµf
�
Þ
tìK‚8Îú,ƒ=bè0eó3w—¯¿"  ‡œ’ ?&›Û.á	Ø
ö
¢YkqŒ¨4Mžá&3îÂ#â/	 ›2Ú¬²î;kleÂ:	ñ	É
b3‡V›Ê&  ±eý7T¡+6TWƒ›	j
§
»
À
ü
W\þF©ËùD¹_¼˜‰ E¿W.YR¨ÂçýDq’Ï ¸ mŽ×ŸËÖ_¤_ß7º˜¤ï]¢¹ ˜äX÷2 g 'ÃFcÄ	‹?îîeäkH&* ½ ‚%@p‘—�ý�k	ESüX—æ‰™±þ58ã¶Æü{¼Û8ôÀÖ ·! � Ï@sÊZj�ü¬Íl±ÆÓ	>	ì	Å
ì
ôcÄ9¤Ú€Š´^›+ • U6Q}3¬ëE $·ÓWÒ/±¹ÔíAJŒØéüg‚ô@ôö‰x,ÜÔ Ù LÃåÝ|à	q	
$²ïõ) NÕð¤R]o!è8C) e ÁX!$R™Ãé)C”š��À8	
‹
Ö
íó'o¯7œ´·ûˆÙ 
 ?që³	e­ÇÎ²±? n .µ¿CÞÎ	¢
MŒ3N·la÷›Ç y -¸9FgQ¨‘	£	õ	ÅE$(]/–Ý'RÿJš÷<Œ3 © ¡RgÏ�–¥ÆÌÝz¶Í º B†­	µ	g
ß
g|ƒš9Z,-é16UËD4Cx9˜é" Y
Š²,@hÏàLS›Ž
LÉÏ©ë„>¿fºø#À F ¬ `AÐßí'Â;ûŸ+³°È AÊÝ#ž		^	uƒ+uBc„9ôù' 8 Ñ h©@	'~„‡��“œŸ¢¨«®±´½ÀÜ ÷
l‰ÝÜ5N´‡K Þ ˆí0#4ÔÉÒùã
 ð �¤ï·Ù
å˜£¬Ê�âhÐÖï¯	"    “3õ/(	¼	â	
Z_r©÷HQŸ'{ÃÎÖ$0™î .0Ae   r~§ú´þŠmsfiÃ;	n	ò	4F4TpW–‰º	—ªéT ž ê ­³éï<}“	ƒ	Ê
â
gÍÆÇpº ÷ œ3“Ûdß*·'
cÖ¿ˆêœàËÌ¹” š Yd)slã´íöwP	ª	Ö	`
nüªD®²Ñ–Ã& ²…þÁÔì U¢³ ,U¼
Á
ý
Z]!`êIªHÌîü º6ñFº fÛ*ÛË7ë„œ	Ô	l¨!PH†’™Š ] _ ÜÒ‹¨
XñóÿGæúÿ7`|Ä½J¸  s 8âXÙ D	w	+
U
k
ë j�PEŽô~	ïYK p úXw 
¤
@Obr“Æ… FŽÀëyovæ9h©Ãèc�<ƒN L �·ÞN7–/"jKÍZ·ÇÀSþ>EYÐº * Ô Óì#Dw”àú	.� a ç ØEOÌ5
C
Isð�gun²p¢¥
2@É<Å C ¹ ü 7`»ù^	!\t�ùLYø À n�ÁÅ„, 
F
8v J£øº~Þ™¡G—Ë‚& 0…×`r¥K„½‰Ð	°àUj»™è[zŽ¥5ò [i�§ˆåG3 h èdE¥Î‹ïfÁÈ uªýT·(ª
Áõ;ƒñv±ï³¿5w©Ù ¦ �ÄG	ö
ž
Œ@Ã²ålžeþ n�5Kš	Å	y
OP�§¹I' kŒ	D#&ú
CQT?äçÿ6˜"­·ú–¾ w Ï Aq’˜ž‘l	º	Ý˜&š²9¸ý½ù—ÿõÁ!¸ ¾ å 5ƒ‚‰þB	jYäe¾s|Ü4×€" u Å ÕS|¸	9FOe‡õý=blŠŒp j«Çèö9�Kµ>›ì8) ÐAt*Uký#
	?	F	[	Æ
é
g`dê•÷0:d¥mQ:ÛÞô©¬·@G_ö$ { ‘ :[‚[†Ž’;­ÎmÇ¥	Î
&?n‡6ßjLW�¥ô!N�Žœ¦  > ¥ ä£²	í	”
™
í
H+/sw{í_Žrp‡•0—œµgmì ! ËHóÿÅ&UÔ“	õ‘Å*€‹b[:1 k Ç Vz4ýx{ÉHi±ÒªÚy	|	Ê	÷	
ñ
ÇÓÕîKg�Ùêõ)A/õ”å÷xLtyšR�ñ9 † Z7~ìFr²ºB�ýÙT-{®" Y – ² Ê JR­Õ	–¸í0G¤ó»Ù1HRõTßwÑ;}ÝÕŠ( 3 R /I	%�ÆÔX=Øl¾hƒblÉÙê
Š­ìøFmMuì
ÄßÌ! ; æ~	M	Ú	Ý	´©ðö¡àãŸÄ<r¿Öñ_ß)p09sD£' H Ú “ç‹˜™Þ×ö¹}£9î-	8
<
m
{«%On~Æ�¥S^ÔáX,Œ¨|îM Q"
-
W
³ùÿ*·w�â>G!Ÿ"µZ, #M]kÇðöºÄKZÕÛá>r		ž	
J
;�‰+?•¡ª¶ÀËÿ"’½<s�’éÒ ¶ ™n0Û>•›Ž¯	
Ñ
*Ý üù…d0Ú6­µõ/% >"%šÄ:QjDOd¾Á9	Œ
È
×
jp2§L�<aÉíÁ".– f üÊS^ *‚	i
¦
E—î¸Qdü% � ” ¼ ÂäYiêDë
Vbîô(.°8�ˆµQ\nˆÚ‰³óš ,>W˜è
ìd®\.Ü³¶ök~" « @É"gÎß@KyšÏ		]	´	fÈ*A58¹ÊB8²ø  Ý £îƒ§ì2ô'	ˆÏÓ®Í/È†@ r|v©	á
3fÌÆ r ÛÀÑáëÚ²ÿê _œ6Oð…îEI·J ) K o �¶Òë"Cvxù6n•ßÿ	£
!iÌ=Xb€„;œ! B û /À+Dqƒ¼ˆÏ	4
øº�4œZ[mFs±‡�–ø?ÈF S¥m4™	
N:O‚�~²¸d¨! ‹�CÔ"ˆRA	·	BNi~†ô<~%o—· 3ø•–=* z )TòZ…‘:"%		Z	’	¤	Í
è
*>_r†)^io†/KV›Ýó¨« aõl�ë# … .yüÈGh°Ñ©ÙH	ö	ÅÆ<Ff0SØÞôS“	ëEstzÞ G "Š¹˜õ¸í!
;
;q(=‘àW+/$ Ž “ ãû=hÉ]9iŸ=Cc®½	h
Ð
Ÿ„‡íP[mÀ!5ò-™¬´' ª ¢í!‚—¦ÍÞ1?J{Îçóu	&	¨	à
c‡[-@ÒÅ7jÉÌ…# Úê¤wÐ5m”±‚»3‡þ	 Nh›Ë5±EWDƒ:>§I( F „ (x‰SBÇÓ„�·!¯Ð!Ø	¶	MÄ)q;}:¶h….<ê2rV§yê* ˆâì<vAlÒ8hƒž°§	(Mp:Êìg„4;?OZlÑi¿ V«HF } Ðã‹ijkqÐÑùú7TUV_gˆ‰œ�†
¾¿ÀÒÓ89ÐNYjk£¤gh»¼½¾ù>? $�‘ž¨©ª!"G" ~ H	ÑäZŒ³áû
Š¼‡
�
ËÁÔÑªcw€¥9@LŸÁ#+ Â-r MW`x
o«…Àƒ‡úe&%’'" I{­ 
~ºå]�ü‹ˆ
Âî(áÒ<«Z´KœAzö Â x–_´ƒ
å
\Ãdl�#“´Üæ±Éà$,  ¡ [ar½ÅÑ�
Õàä6~Úxa:lk . ­ ÒâBÌÐüè ,¦MQ� a�Ö$œyó	°	Ú¨7õŸë ‹ í{·+NaÉê2	_	vyÏ„É Cê:„“( >Ãð:ËÞ„.sXoä 	p›°,vE¬W«&ûfÌPú&a B!Ÿ†	
€A‰Á†dÁ…½ˆ'£P!  +J®/c»žª°4ÿÂ	ï	ÐŠÖ6¯ÉÓ=[ìÒV\/ § |'¶A^…ˆŽ‘”� £©¬¯²µ¾ÁÝ‰
Ãm}½)O¬éL�B_÷þ Ò ƒæŽ(ÉïµÁF LÃ 9 åi
ýŒ¡<ï
ø
$-luèÞÝâ�µ-{zˆ¼¡ @  ‹—‰l˜æ
1]�mò†C¯”µó- <y&µ„
�Xe‚25ÏÊ$iä²% ß ')ã$æ9úMÄ$[]á á `çîïÉ#ÕÓúÝçÊÐ ¢ í ô o¤÷±ûLÒ‘
›
Ú
·€Ž“&NbÂm«æû ñ ÿ P]\ðbsè€ÆJá7^™ð°;iã € ¹ž¸æ™¤­ËÖÛäSÑy‰@
¢î> ¥¾ï­
²
�åÄ
µãi×—Úl¬  WV¥´5	h	–
Í(sÑE!ç\t~ý¡§¯Ñ·/& 	×à{Óó%(4Âü	½	ã	
`ÓIaÆ	Ér±¾é-žN‚ïO
ò$  / N ® HÏ;ãö0ÁZ?
†1y[ª´R (¹UGÄ×%R‘šä1fo  ”C^Ì)	1¥OÏø$¤|Ï1«V`B  Ö C½˜×%�nzªûjÄ	<	o	ò5U—W*àÕß½ bbe‹é(g±	ó	5RXŠÌ%˜‚ÊöÐì s¨ûLµtIô®GSq,  U ã ‘îÿ7cÛ“ñ»
©8«J³êÂ –ðeOëË
hÊ(Çë;q±”  , ‰ Œ Ÿ îê=€sÖâèñ	0	„	ü	ã
wÐ…ÇÎau~¡…) ë :Õ%Fy®´J~Ê3	À	!\Düñ< |¸,b”`	uzÈ0» ÄGNŽ~à(
v
qÀ-y‰wë’pÝ×ädt•b ø ;iÌßpåT	Š	×Ì¬'2Í ?�Ë4<Üö…õt+¸!	wFÍgQûv # ”ñe/ðYæ	p
d|œ±0�­XáüºRŸ'UÌÒ › ZOÊ ×	oE¯ÜËe—ŒüÄé6 `Í›º½".däÇîWQ	W	‡	BŠ³×‰wá(¤| *m¦÷�	÷¹ ÂÒ‡_+�P e¬Ctµåñx–b	•	«	
a
ý�«@Â†¾Q] ¯0€¼�¨Ð¶
½
Â
Ü
ó
þ
!"§Â•÷>¡òAÄv‡( c ,³†Ÿ«±ÿí>P´-kÜÌ	ð	e
KasëJ%‹«7UÍà1çò   d6ÂÕV£5VbšÃ	[^¹Ê\¡íæCp‘jG»ÎW—% KTÎ?rÉ5P|€ûß 	ÑIM‹×°Ôïý4âz»7Ù çÓB] m ·ÀBÂ8�	¢	Š
¡
Än•MQI¶`‡š°>‹$ ¨ Ü	Q_‰±Î+€•¤ËÜÌ¹…�¬	‚&*{+êžTCÇè$ 7 ï g}†�’ž¡ª­°³¶¼¿

/—É^~ÜÛöP"zÕøÿd$ ™ é ö Xq}¦ù(’³ý‰Þâ³ìõÕ	_
mEÕ¾©Cˆ­ß–èo¸“S \ ^ ÚÓÿ)Ê*
Yéðò HiíûŸþ G{}‘ Ó Ý“vù	?J¶Æ8NaÅ¹M ` „ÄNJB
E
içyI÷ÿ o¤	K;Ä ç�Œx
�
©
ôðu°D¦ÂŠ�¾4vý t Ä jù
aãdi½çùõœJš½    ¤ 9Gãþ�ÄE	“
%.mvé5�/ÞìP”–¤óMfZ  2 Q X ± É IwzÔx	{	É	ð
ì×k�½º(Q.w
Q|ð­‰Ë' : ÆæJY¢ÔÚ=~	,
7
I
V
l
z¨þß!žÃ‘¶¾ÅFr�
´r§{Ñ¢L µ » ˜m/¥
)Üû-‡Pc. =x™
2Û4.Ç} A q ú ŒRêøp
3
é^9�Ž›°†•¶ !Š€ûYç
A…n×óDòs”ô E ƒ 'ú È4LžÄ‚=„³ GÁ‡áup^‚w
…
Ê½fƒ3:iÐ8=KUd%ÿ& z^‚
[ãÙYçJ`›€k’jå =�ì9z¶ÎÙš¯V6ªé%ËO  *‚ä.È3#kç¼èÿ^Ñ[» à (#%k8æ—ùœLWÈÎZ\ ó þ ¸öO\çî±
�¶ã	´’%MÁ?¡hâåú! M ßUÎò:û0…NDÎÅ[}¸½#T£®ÐF�UNñ Õ â B¼íKadè©úHbñðV$)²ßÏÔÞ + ˆ 9Ô$Ex•ráçû	t`/°û	 ;Mï/sžuËÑ _V	Œ	ÿÊÖ^vàûè5 b Í>qÈ§Û
J¸$¦”3ñáÃBoiÍA ˜ è î õ p¥ø‘²üPˆ°Í»^
	D–�õ‡µyÔ=Æç [ ÃÙMD
œ
hItCHž¥Ÿn£3ü £ Ã FvÓ6
H
’
y§4�`¼½'Och¼v£³q™¦¬ÊÐ ´ º Q.é÷Ûèú8€ñ D ‚  ]†ùtÇ3�
KZ¼ÍØâ_š7<Jj‘þ ò ý -TñÇ›âæLV¼
"¢ÏTMZäðù 8A»^LcaðU_]±ußúr4t Â p�ÂÇ‡¯ºG
C•¦#3
¤»Až¢Ó˜Ì � º…ø-
ÚçïYšÌ×áåTK6ISýsï) Á oÆÒ¹9:”¥ÜÝÞßà !"2T	ÛŠ‹Œ�€š›œ�Ú5HŒrÚÛ! Ÿ6ŸÞÓ¡}
’˜¥º;®UwÜÒzŽùy�ß$=Û£�xƒÜ? Ì ¦ÔŠÑ	“±<¯Vx¶	{j¦Ó÷9ó,\jb¤‰#H ØG¿ðL…¾	0`º#	ä{�Ž(¨×ÛiyÝ" s¦-]0
®
³
™¦V‘æÅšÝz„�’å6˜%>ÜmŽ­„$ 1† 7 ß¢a«×Z
~
œ¡»ák¼é\JØúzÍÓ‚àæÖ4@  Õi	ê	Î‰°W·Ò2ø€¢ìô-]c$ W§e‹¦µ6	%
ún
"Fè§ÔÏ¨I ééÒ	tF£¦NþŒðòg°¥Â¸ÆÉ0W i Í XK	—
”©²)=yj|]ku:×ãkÒŠ ' )Ù†

ö<„òJb
.´X�îƒ”Ü6jó& 
v«Øþ|¸Ô)5HÃñ1a»	$	Â~4|a…²¯ÇOð¡Ú+Þ áU&À¿ý«
²ÔÇå+¯¿êðA©ØTxªÎ –gôM¾	ä	w·Ês|�ZnÛŸHþ)ÀPz" 0 5 O ¯ 3‘<HtùÂ@
Ÿ
´
çü\ÚSÞ“ŸÄHOæm›å�®… I!ä1÷
1
¯
'È�{æ™ÕÝSŸf  ÐÅ1©.[^šWf’A…�7ºË³wØ&pÎ2gpÔ  % §1§÷
è	§‡2zÆ›«µ¡)ú&?VÅ’n)ÿ 2ó•ØŽ6*	›	âž³½È�êùÎŒ¥}Wá+€5 ¡¡©àobòLPlPÐÙ¨{%ƒoº¬]aC 8D[_ÍÆ	[
z

�¢]­ÀKûÔüÐ2J (×   T ‡£¬O
r
2�¼Ö	QZ‘¦?dáî(¼çA  × ™ØQß	UÏBV€¡™#�®.áÖuà  Ú'X3 ù+d2¾  D¾l�
Ö&žEû
6Š>X¸í^§Á—ã%' $o{�«ÌükÅ	=	j	p	ë	DR¶ó±Ÿ¸Óì@åèû˜ó7£õû+¿Õ x êBf“™€Œ§7	²	ô	ò6Æ#'›‹Í&þ™ú ;öÆ XfAÞ™YtÁ:¨¾ƒ÷"E  Ð ¨ŒŸ»	ä«G³gÕ˜Ñí-J  � ccèr)h’¶	O	m	‚	&
ûSo•é±¹Ð©Å•ËÂ¹ „ŠØêÿC	v	Ó	T
kåG§ O�ó5Ã¹X
 €Mêu-å¿g‚ ¿ æ 6ƒ
¯HTuZrÿfñt}ÝhŒ¦¡Ê1� t©ü¶JõÀ¤Í±ÀÇØV v Î ä 4{¹	8PdÜ>k‹!ª¬r´þë7 =  T¢˜
Gfz”öc�lq9¶?œF¥9# j Æ Y
qŒ•£òØGakvÈÐØäé¬÷:Kl™LŽë	Ã81 P\j’ïõ—Ö8},	L	�	Ù	Ü	:€ˆª³*>” ©µ¿Êøâþm}^v€¼Þá;Ž žÓY‹í ÚPNÇ
ê
DUai–ø1¦Kc€/;`ÈÙì²•ô Ü +ÈVf	\	eëË)µõ­¸A7÷ ( J Ñ!Bu*l¿àÙþ˜	÷¹}Y<Zïr„ícŽHE* —ñô‡$ì@	G	Y	 
:
Ì
h}=^…ó;epnR’U�Üßª•*.Ý`k~* � ’ Ùé£w\0>I�“æò<�®Ï2bt¼×		%	ý	Ï
Ãb††µ°q¦Èñ¦,& | Ïâë;ø	6f‡¯»¦	nÑ'o7bvªMX¢‚†��§* -   w•¬ÿ}¹\qÄä
5}Ïàk³Pyõ"Ûß Š `Õïƒ›*nÈãéò1	…	¯	x@ˆÈÀD§¼Ožê¢` ¦ &b�¯µ;þÁ	î	î
,tÏ|Õ�®È,ÀëEýUy ? &;ŠâåŒîñ"1…B®hòÏ ì n£°úKš
¬
IÃRˆ–]˜ªÙ«í=( ÖGVz$'Á]ÀY¤³Ë	4	g	>
•
'0x¤³Ò `æsÈq°�ªã_¶~	n —'6­R’Q+ËI�ÉÿÁ¼ Id Õð/	¿	Æt}[' ð; " ÊFh�õ}ôS	‰	å	o
u
v{x‘oÜÖã1QcT «Ìš¹¼-cN¥ÆÉäðV•a	”	ö¸Û?‹*Œ\{O* S4O{�5=OúajÞ™ÏÛË	d
µ
ò
 rÁLŠTßö 0@yæuØå�æ–†% 6 l W¿|Êá²¸ô«�	¡	
 
.ÈÔ]Û%zÚ*B”Þ•Sçn·¯cR ’þuIø	)
A
w
>èïh¯xìÅöý‰þMzœu�:# 1 P W ° È ÅHIyÃÓz	}	È	ýÖ.ŽÂë¹Ä“q•æø	›IPòLe ù <o
2
(„,šÖÚ3-| 8à]�
É™®ØIU$T  õ["jÍåí2ø°
„Žµ³»C‘|çÍ­� g ‡ :J¨ùGqæU	‹	sþ(.ÞÎ¯ Z — Ì=¦u]
xgH¥_»ôB¼2†Gà´xhÏ ³ @,KSÆö2U»¡Î~Þq3# ž5ÝÑ÷†®|
‘—¤¹ÙîBX“1ÚSx#<ÒÙ4R‹üqwÙ" Ë FªÖ,/\_¹"	/
Y

› Iyƒ‘äö8ÌÒ+a'Ö"hÕ èJ	é	$
¨ùˆm1i¢MÖâëñÅV  & •f}3{¶„*®YmÚ®@GWÆíý“S *Í  $ 4 020¨øç	&ÇeûÙžÔÊùNvoÍ(Ó   S ¨òñZN
q
ŽÕY�²Ç>œ¬¿c‹íû'n»\à* ÙP�ËÞ	µAžë ú=ò*¦À~1tâÔ  œ ç@	N	�	ãªñÅs”Àf°Ä”:,ÅD ×u	
S
¿äÌf‹¿�2 < 3O[iô–7z¡+	œ	Ø	Û	
p‹“Ÿ¨´¾É÷¢á×F`ÝàuÏq�˜�ýXEê7¤6' I Û  Ç¾ßØóMX	—	9
|CT]¸o|‘T_ØYì)-b�D} _”è¢Îávpš÷/e®ºå®	 m´¿C©¦p»xé¥_ %m‰¢a¯ùœ#\:Xf	=
&‹£ÂÎQÑ­Ç„­â^©}# ÉªEŒ™»c~¤Èãïï.	R	ˆ	n
t
5¬QPÚ>&ÕâŠïSN# V R¾N`·Ýó˜ÎŽ	 	Ç	c
=-$®Á¸Ãü?ˆ”åý¶KQ  ô9\n§ø€
ƒƒ´˜­+H#,Ž +¥E.
X
\
{
�Ÿ£ØA^ºx‚ã"* `Ñ3!Ø ç#
M
øú LÓÕð[)  NhÖ?yt	€	

R
Š¾’§@ “etÃŠ“¿¾ÓC' $^lˆÈ®øDuÆ­[âe	–	­	s
4ÿS\¢·ÁÍ¬¾=BëèR^  U ó½¤M¶Üæò—Ÿ	L
b
<‚ž×,@‚—¬#“äï)+  fgñò­÷»¼ÅLc	d	s	¬	K
P
Q
3½þ
R[–«ÌA�‘’âã‡ˆ‰½êB  .  qGACNNNNNNGTC,CCAGGCCTGG,GATCCGGATC,CCWGGTACCWGG,CCANNNNNTGG,CCAGGNNNTGG,CCANNNCCTGG,CCAGGNCCTGG,GCACNNNAACGTTNNNGTGC,CACNNNGTG,CCNNNNNNNGG,AACNAACRYGTGCGTGC,GCACGCACRYGTTNGTT,GCACNAACRYGTTNGTGC,AACGCACRYGTGCGTT,GACNNNNNGTC,GAANNNNNNNTTGG,CCAANNNNNNNTTC,CACNNNNGTG,AACACNNNNGTGC,GCACNNNNGTGTT,GCANNNNNNTGC,GAACNNNNNNTCC,GGANNNNNNGTTC,CAGNNNCTG,CCAGGNNCTG,CAGNNCCTGG,CCWGGGCCC,GGGCCCWGG,CCWGGGCCCWGG,AACNNNNNNGTGCACNNNNNNGTT,GACNNNGTC,GAANNNNTTC,CCWGGTACC,GGTACCWGG,CCWGGWCCWGG,ACNNNNGTAYC,GRTACNNNNGT,CCWGGYRCCWGG,GAAGNNNNNNTAC,GTANNNNNNCTTC,AACGGCNNNGTGC,GCACNNNGCCGTT,GCACGGCNNNGTT,AACNNNGCCGTGC,CGANNNNNNTGC,GCANNNNNNTCG,CGATCNNNNTGC,GCANNNNGATCG,TGANNNNNNTCA,TGATCNNNNTCA,TGANNNNGATCA,TGATCNNGATCA,AACCTGCNNGTGC,GCACNNGCAGGTT,GCACCTGCNNGTT,AACNNGCAGGTGC,GCCNNNNNGGC,AACNNNNNNGTGCMC,GKGCACNNNNNNGTT,CCWGGNCCWGG,AACTGGGNNGTGC,GCACNNCCCAGTT,GCACTGGGNNGTT,AACNNCCCAGTGC,GACNNNNGTC,GAGNNNNNCTC,CCWGGTCTC,GAGACCWGG,GATNNNNATC,GATCNNNATC,GATNNNGATC,GATCNNGATC,CCWGGCGCCWGG,ACNNNNNCTCC,GGAGNNNNNGT,AACNNNNNNGTGCAG,CTGCACNNNNNNGTT,GATCATGATC,CCWGGNNCCWGG,AACTGGNNNGTGC,GCACNNNCCAGTT,GCACTGGNNNGTT,AACNNNCCAGTGC,AACNAACCGGTGCGTGC,GCACGCACCGGTTNGTT,GCACNAACCGGTTNGTGC,AACGCACCGGTGCGTT,GCANNNNNTGC,GCACNNNNNNGTTCGAACNNNNNNGTGC,CCTNNNNNAGG,GCNNNNNNNGC,CCANNNNNNTGG,CCAGGNNCCTGG,CCTGGCCAGG,CAANNNNNGTGG,CCACNNNNNTTG,TTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAA,GCACNNNNNNGTTTAAACNNNNNNGTGC,CCAGGNCCY,RGGNCCTGG,CCWGGGNCCTGG,CCAGGNCCCWGG,AAGNNNNNCTT,GAYNNNNNVTC,GABNNNNNRTC,GAYNNNNNRTC,GATCNNNNVTC,GABNNNNGATC,GAYNNNNGATC,GATCNNNNRTC,GATCNNNGATC,GTYAACNNNNNNGTGC,GCACNNNNNNGTTRAC,GCACNNNNNNGTTAACNNNNNNGTGC,GATCNGATC,TAACTATAACGGTCCTAAGGTAGCGA,TCGCTACCTTAGGACCGTTATAGTTA,CTCTCTTAAGGTAGC,GCTACCTTAAGAGAG,TAGGGATAACAGGGTAAT,ATTACCCTGTTATCCCTA,GTTAACNNNNNNGTGC,GCACNNNNNNGTTAAC,AACNAACGCGTGCGTGC,GCACGCACGCGTTNGTT,GCACNAACGCGTTNGTGC,AACGCACGCGTGCGTT,TCCAACNNNNNNGTGC,GCACNNNNNNGTTGGA,CAYNNNNRTG,AACAYNNNNGTGC,GCACNNNNRTGTT,GTTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAAC,CCWGGCGCC,GGCGCCWGG,CCWGGNNCC,GGNNCCWGG,GATCGCGATC,AACNAACATGTGCGTGC,GCACGCACATGTTNGTT,GCACNAACATGTTNGTGC,AACGCACATGTGCGTT,TGGCAAACAGCTATTATGGGTATTATGGGT,ACCCATAATACCCATAATAGCTGTTTGCCA,ATCTATGTCGGGTGCGGAGAAAGAGGTAATGAAATGG,CCATTTCATTACCTCTTTCTCCGCACCCGACATAGAT,AACNNGCACGTGCNNGTT,GAACNNNNNCTC,GAGNNNNNGTTC,CCAGGWCCY,RGGWCCTGG,CCWGGGWCCTGG,CCAGGWCCCWGG,CCAGGWCCTGG,TTATAACNNNNNNGTGC,GCACNNNNNNGTTATAA,GCACNNNNNNGTTATAACNNNNNNGTGC,GAACNNNNNNTAC,GTANNNNNNGTTC,GGCCNNNNNGGCC,AACNNACTAGTGC,GCACTAGTNNGTT,AACTAGTNNGTGC,GCACNNACTAGTT,AACNAACTAGTGCGTGC,GCACGCACTAGTTNGTT,GCACNAACTAGTTNGTGC,AACGCACTAGTGCGTT,AACNNNAACGTGCNNGTGC,GCACNNGCACGTTNNNGTT,GCACCCANNNGTT,AACNNNTGGGTGC,TTAACNNNNNNGTGC,GCACNNNNNNGTTAA,CACNNNNNNTCC,GGANNNNNNGTG,CACNNNNGATCC,GGATCNNNNGTG,GATCTAGATC,CCANNNNNNNNNTGG,CCAGGCCT,AGGCCTGG,CCTCGAGG,GATCCGGA,TCCGGATC,GGCGCGCC,GCGATCGC,CCWGGWCC,GGWCCWGG,GATCGATC,GATCATGA,TCATGATC,GCGGCCGC,CCTGGCCR,YGGCCAGG,CCWGGNCC,GGNCCWGG,GGCCGGCC,RTGCGCAY,GATCNNGA,TCNNGATC,CGCGCGCG,CCTGGCCA,TGGCCAGG,CGCCGGCG,GTTTAAAC,GATCGCGA,TCGCGATC,TTAATTAA,VCTCGAGB,CCTGCAGG,CRCCGGYG,CGTCGACG,ATTTAAAT,GCCCGGGC,GATCTAGA,TCTAGATC,CACCTGC,GCAGGTG,CCTNAGG,GATCGAT,ATCGATC,CCTCAGC,GCTGAGG,GCTNAGC,CCTNAGC,GCTNAGG,GCTCTTC,GAAGAGC,GGTNACC,CGGWCCG,ACCWGGT,RGGNCCY,CCTGGAG,CTCCAGG,GGTGATC,GATCACC,GATCNGA,TCNGATC,GGGWCCC,GAAGATC,GATCTTC,CCCWGGG,TCCNGGA,TCCWGGA,RGGWCCY,TTATAA,AGGCCT,GACGTC,GTMKAC,TCCGGA,TGCGCA,ACCTGC,GCAGGT,GGTACC,AGTACT,GGYRCC,CCGCTC,GAGCGG,AACGTT,YGGCCR,RAATTY,CTGAAG,CTTCAG,CACGTG,GRCGYC,AGCGCT,CTTAAG,ACRYGT,ACCGGT,ACTAGT,CACGTC,GACGTG,GWGCWC,GTGCAC,CYCGRG,GGGCCC,ATTAAT,CCTAGG,TTCGAA,GCTAGC,GKGCMC,TGGCCA,GGATCC,GRGCYC,ATCGAT,CACGAG,CTCGTG,GGCGCC,GAAGAC,GTCTTC,GCATGC,GTATCC,GGATAC,TGATCA,ACTGGG,CCCAGT,CTRYAG,RGCGCY,AGATCT,GGNNCC,CTGGAG,CTCCAG,CTTGAG,CTCAAG,CGATCG,GGTCTC,GAGACC,YACGTR,CCNNGG,GAATGC,GCATTC,WCCGGW,GCAATG,CATTGC,RCCGGY,GCGCGC,GAGGAG,CTCCTC,CGGCCG,CCCAGC,GCTGGG,GTGCAG,CTGCAC,CGRYCG,CGTACG,CGTCTC,GAGACG,CCATGG,TCGCGA,GDGCHC,TGTACA,TCATGA,ACATGT,GTATAC,CCWWGG,CTCTTC,GAAGAG,GCNNGC,CCRYGG,GTTAAC,RCATGY,TACGTA,RGATCY,GCGATG,CATCGC,GCAGTG,CACTGC,CCCGGG,CCGCGG,TTTAAA,GGCGGA,TCCGCC,GAGCTC,GATATC,CTGRAG,CTYCAG,CAGCAG,CTGCTG,GAATTC,ATGCAT,CATATG,GTYRAC,AAGCTT,GTNNAC,TCNNGA,CAATTG,ACGCGT,TCCRAC,GTYGGA,GCCGGC,CMGCKG,GCCGAG,CTCGGC,CTCGAG,CTGCAG,CAGCTG,GTCGAC,CTYRAG,AATATT,GATCGA,TCGATC,GACCGA,CACCCA,TCGGTC,TGGGTG,WGTACW,TARCCA,TGGYTA,TCTAGA,GGATC,GATCC,CCWGG,GTCTC,GAGAC,GCWGC,GGNCC,CCSGG,GGTGA,TCACC,GGWCC,GCAGC,GCTGC,CCATC,GATGG,ACGGC,GCCGT,GCNGC,CCNGG,GCATC,GATGC,ACTGG,CCAGT,GGATG,CATCC,CTCAG,CTGAG,GGGAC,GTCCC,ACNGT,CTNAG,CAGTG,CACTG,GACGC,GCGTC,CCCGC,GCGGG,GANTC,CGWCG,TCNGA,CCTTC,GAAGG,GTNAC,GAAGA,TCTTC,GAGTC,GACTC,GTSAC,GAWTC,GCSGC,CASTG,ATGAA,TTCAT,ACGGA,TCCGT,CGCG,CCGC,GCGG,GTAC,AGCT,GCGC,CTAG,GATC,GGCC,CCGG,CATG,RGCY,YATR,ACGT,TGCA,AATT,CCTC,GAGG,TTAA,ASST,TCGA                                                                                                                                                                                                                                                                                                                                                           *                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               	                            	                        	                                                                                                                                                                                   '                                                      
                                                                                                 	                
                  
                              /         	   	      	         	               	            	               
                        	                        2         #   "      "            ~   U                )      Z                                                                                                                                                                      *                                                                                                                                                                                                                                                                                                             	            	        	                                                                 '                    
                                   	      
      
          /   	 	  	   	     	    	     
        	        2   # "  "    ~ U      )  Z   uÄ  vÒ  vè  w  {R  €  †HFª$N×zØ	<‚Éä¦Tf#¹åNä•dLJ ßpÐß™ÂQ–MÇ0Pó–llL±&n¾ MÇçkƒ‚ö‰ÅÒþñ
	FHr�«&n¡ðöîBYäê_ƒ²½>j¾s¬0}mÎ	:	©¹	¢
©Ç¹	©¹©©Zb¯åNä•	®¶U¼T_ôC�M?..Ý _HQ ñ$	w
V¾Ž	 	² ÉZ, BÂj	
NZW\+Ë$eLLj›V(r§ú´TÇÎWØaš Â•œÊWj
ôüDŠ‹`–ÿŸ{ 	ŸMÔï£B~ ¼ÔwÊ¸«z*Shr§ú´üº	ÖTÆ2ã Dø  -‘	j(~Y ~Y@

ÿ \á^™i+¦~ XÙÒ

Ã ~YM’-¸

ÿ
#ÒfËèMñVüzß
í
+sŽ/Í	
^ŽÀ–	·ëju>.M¯Ô~†üÆ8 ôÊ’Ã_Wq	

j
ÓßôWüDb‰Šèä2OÛË	0ñ´„®Æ*-qK+aœ¥MPÜ—Îb
SÎñ+@ ­?ä•Ø¥á[ßôªÊ´<ñŠ!CŸ\ñ
õt D	ÃŸí•-ÂaœÎ­Í  -¸XÙÒ‘	

ÿ
#ÒÃ j(f~Y“ù	DÇaœ¥Î+­¨ÊÓ–Z,w Mz~Ž­ÎþB	I	8
é
í
{‰´+`s‘K&hnŠŽ·»ñs�ýSx¥,aœÎ­í
+sŽDK ’ô.'	Y¨ž&ÂÍ#//@Ï ž²V•
'sýGF‘oc@…
6Iý%þó•6*	›	ž³½ÈŒW-OÊ¸«ÛË	z*0SñhY	^Üªyz	È	P-uâç ÎW ç ÀÛìKvœ	O`ÇÎ~cYW  Í <HØñé$	Ò	
aJS¦Þ
d…Ê€-³wÇ  ã ºa I´ñ
e’˜�7~ðÄ9é	.e’ÎWÆ2„®´Æ*àFš ®Ã”	\‰ì$¯§÷‡) Ò"Cv“ßù	œ5|^¹\W
 ’.á	Yq¨ž&Â#/ “(	÷{Î0 ARN`ÝM˜Îc
CT?_Øå¦	þqeÇ xÒ#?	F	y	|	gÕ:d�êmQ”å÷šÛÞ©ñ_Ø LÃÜkàq	Ä	


#è7H&PÞ	@A  ¿tÓe6ƒ›	˜‰M·)zkÄ	H&#?	F	g:dmQÛÞ©_Ç xÒy	|	Õ�ê”å÷šñ#\Xf	=
&£ÑÇâ^}©‰5nzªûjÄ	<	o	ò—*ã; Ç x#Ò#?	F	y	|	Ú	CQgö¡Õà:?d�äçêÖ6_mßQ”å÷úpšÛÞ©ñD_¾£RNP`ÝM˜ÎÞ	c
CT@A  ?_Øå¿tÓ£²	”
/w_rpœµm8 h	 ÷
ÝÜ´‡NŽ~qÀ‰×ä•I  ¾ßØ—	¸|Yìb�D?&›Ûö
k4M]Ë¤ª_~& Wí“l ¿�	¡	 
”¯š1Ù†šP�C½%�(
v
5wëWËe;qt& l ³ ¿ö�	¡	 
”Wí“¯¿àÙþï„íHF�}u
x‘oÜÖãcþº	ªé×Nhy
Š’§tT˜"­¬ “d¤AMcâhœÖûŸà+·¹rhm	So•¤¹Í©ÀÇVY5 Ÿ
âW\Ú2“ø´cæm+6®E.
X
Ÿx‚ã*`!gB­g
ƒ4˜7ŽëyëÔ	`lv¨^©è\t¿ù’N© ¡�–¥ÌÝzÍ	ß
Z,6Ë©.[^š�7Ë&gÔM·“dcœà¹ëÔ	lv¨¿’¬ ¤AâhÖûŸ+; #Ú	CQö¡à?äçÖ6_ßúpD¾£F�}¿àÙþu
x‘oÜÖãï„íHc§ ^”£)é�B¿¾ä¨× ½€v Î ä 4{¹	8PdÜ>k‹!ª¬r´þë7< 3O[iô–7z¡+	œ	Ø	Û	
p‹“Ÿ¨´¾É÷¢á×F`ÝàuÏq�˜�ýXEê7¤6kŒ	D#&ú
CQT?äçÿ6˜"­·ú–¾* Ô Óì#Dw”àú	.�… .yüÈGh°Ñ©ÙH	ö	ÅÆ<Ff0SØÞôS“	ëEstzÞu Å ÕS|¸	9FOe‡õý=blŠŒp j«Çèö9�Kµ>›ì8ù <o
2
(„,šÖÚ3-|   “3õ/(	¼	â	
Z_r©÷HQŸ'{ÃÎÖ$0™î .0AeÙ LÃåÝ|à	q	
$²ïõ) NÕð¤R]o!è8CÙP�ËÞ	µAžë ú=ò*¦À~1tâÔ¦ &b�¯µ;þÁ	î	î
,tÏ|Õ�®È,ÀëEýUyG … • Ù "LU.6Qy}Š¹Ãå3˜¬ÝüÈõ¸ëGh|°ÑàE©Ùí	H	q	ö	
!
;
 $·ÅÓ$²ÆWÒïõ)/<F ±¹ÔíAJNfŒØéü;gq‚Õðô0@ôSØÞô(=S“¤ö	R]o‰ëEsx‘à!,WtÜè+/8zÔÞC ? ¦ à &(*;‚Šâä&.b#%k�¯µå8æ—È3;ùþÁ	î	î
œ#,ktŒÏçL|¼Õî�®Èè,WÀÈëñ"1E…ÎBÿZ\^®ÑýU[hy»òÏs¨ûLµtIô®GSq,  U  ¤ 9Gãþ�ÄE	“
%.mvé5�/ÞìP”–¤óMfZ ¡ [ar½ÅÑ�
Õàä6~Úxa:lkç#
M
øú LÓÕð[)e ÁX!$R™Ãé)C”š��À8	
‹
Ö
íó'o¯7œ´·ûˆÙD ‚  ]†ùtÇ3�
KZ¼ÍØâ_š7<Jj‘þf … s¨û*Lµ.yüÊüS^Èm *Ght¦°Ñ÷I‚©Ùô	H	�	ö	i
¦
®Å÷GSÆE<F—fq¹ ,0ÂîSÒØÞôS‡“	¸ëEQdsü_t +�z ÞPUW§e‹¦µ6	%
ún
"Fè§ÔÏ¨IX  +¼        ø        ø¿þ`�îÒu¸îód¥=&ã¿ŽˆŠ,á$ŒÄÕjS�uC¡ñÖ�…ã¤
C*Œã¬Æ'Ñ™Ì¡Úhy)¥’[Zpi+dý™�+Ì§eéÂVÏƒ‡Ï×üý¡ËYaÉŠý’\õ�¯hrÖšœ%xýè4�µ"m˜õ'?ù¡ËXp•ƒóàÚcô�‡é€z¾z'nri-³š}‚Â¨4�µ€È0¨{p¯RïÚµ€JŠ ßUµÀz½V,—^óý¡ÍX$2'.fSDîàåäEýã§ƒ¦ÅigÞdSƒ“*T÷€o	ÿBS¬ÞÄ AL0BæM@ÄŠß ‚?o‚ÄàpÇ%p÷R´È¼11�~pÔáþ­¸ß|58ü�àýþÈ}þœ24Ž´óŸñ÷aM7ºÔ¼ö?9ËÐLßnºÔp×�Gó<B¬@Ç‚Í±8P6Ç­Avøu8uç]=×.fØ<u4QpÛP…ëQ¼÷]±24ìñ÷ŸMöÃ?Èã�Ç_yøMý/?„ÕõÄS1·`¾8²<ð{°ØN'RK‘ò¥8m>Çˆúä£ÓÛŠ*?ïü�¯¡þ÷¿x¾¯–U„£lÚ.B-®k€ €45 hdÐØà0€î`ë„0T_N î@	¿ÜÏâL3iLÃ ‚œÍ29Þ�LþLüï«:ºþ¾®Ïr³Ã«üµ;•°¿©¼jHêpß±ÿU^†�!‚·$€öÏá‘ÂªÏê KÜ®¥’º+Õà]wµþnÂæº¡©”¨ñ«š
UXN—Uj\Å¥® Xˆ´¤�RÿC¿ÓCE&5M�»ZKM}�RÿC¿ÓCE&5M�»ZKM}’üÿ—¼ý¿?åï?Jóö»ÏöZª¦¦4CÄ<û�¸NkÑI!:ª>Cª5TïÀN‰›Ú¬†ÔGA„*Í†…Ô`hÜÐ®ðó  D9¬9‡€Ýtu°ã¸cÏ"¼8´Í ÏÂº¨µ‹Â?……ãAÄ4Ì9²qÀÊú3N#±Ê-áLàãš� Ðnø¶íú;ãÄT›Û`á�c8ÙÎ†ðçãö±÷ÔÅvÍ±17'°`SÂè±´nM´³=<^+=Ô36?1ì²Ø1�Ž�m‚X<ê¸Û ðà"9´“(9ü†háDè0Å€áó¯²:œ&Ï;ñ¬Ó6Ï®lúèq+®î ¬VSý~=·«÷Ï>¹…B€ë²«ÀsÃ�†ûÓ0íŽ®³÷ýz*hÓ¦X)Õ•5“mÕ«ueMª«xÚä¢
‹Õíµ‰ºm‹‰Ÿ,~ääNƒ%¶dâ¯ˆ…h¦ó·Z÷uÙÄðSeH•> �–—·ihÊ3·�Î¯K_‹#Ó�¥…°õÌÀ*2hî¼ëìíáìã;+0ÄÂm;{T0–p¦÷E´—4bUMT=òUCÌ£ƒ*¯d;Ïÿ‡mÕ[íKD Å™QŸC*ÿàS¿²3»â¼�:|ø¼ú»úÀS Î®Ù;s‰	»JÂ$,¬ïS€â#qü­?8Ï¦ð—›.„½	Gqé³Þ4÷‚]“DÄ&$0ŽtJèR>^pçy]& ›Œî8SÒŸ¬Q($î†ðÕÕ÷Î	0ª¨¨ÔÓFœÍUíEêªç ¸s´�qW·)@j‚ØF›UAºß‘¾©ZUaJ¥mnT™˜I^‚áÒŸXém!ù»Ln.jÊÛÙ(ø{ü²$eçÀ@éöàÿHãXgÌG÷;|;Ñ©´ÖWÓÓÁ@ñ3E ¾5êo>öô¹¥¢�ND”’³Ò–JŒ×(£Ú9ÐÛ ‹s²Ê‚`ëkNð¯×PÄ§a¿ö(�UL);ëï(´RRƒÍ"›{`¦7�–»§‹cÛÉF:®!à„ž×Ô¶¸E’&0ÇÄ£º?µœYó=Ù4^¥R;m UÊë Å^íAº|â„oJÆ%ýì�ýxn´Ûªz·Ó*à!5WACU�5UeÁX¡g¶{¯ªµšhSjmš.ØLÙ¨Xš‘U•Õ�
ó7jÿH÷áË      ÷  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  !º<?xml version="1.0"?><Features nextValidID="19"><Feature recentID="18" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4006-4022" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3982-3998" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="T7 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="863-881" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4075-4096" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment name="-10" range="4030-4036" color="#ffffff" type="standard"/><Segment range="4037-4054" color="#ffffff" type="standard"/><Segment name="-35" range="4055-4060" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6001-6105" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3812-3933" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2628-2763" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="615-818" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="bGH poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1736-1960" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bovine growth hormone polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="SV40 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2448-2777" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="235-614" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="f1 ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2006-2434" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="RIGHT"/></Q></Feature><Feature recentID="5" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4384-4969" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="LEFT"/></Q></Feature><Feature recentID="4" name="EGFP" directionality="1" translationMW="26941.53" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="0" hitsStopCodon="1"><Segment range="979-981" color="#05fd14" type="standard" translated="1"/><Segment name="1a" range="982-984" color="#05fd14" type="standard" translated="1" translationNumberingStartsFrom="0"/><Segment range="985-1698" color="#05fd14" type="standard" translated="1" translationNumberingStartsFrom="2"/><Q name="transl_table"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mammalian codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;enhanced GFP&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="3" name="NeoR/KanR" directionality="1" translationMW="29047.90" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="2844-3638" color="#ccffcc" type="standard" translated="1"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="2" name="AmpR" directionality="2" translationMW="31557.36" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5931" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="5140-5931" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="5932-6000" color="#ccffcc" type="standard" translated="1"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="1" name="linker" directionality="1" translationMW="333.30" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="1698" maxFusedRunOn="1698"><Segment range="949-963" color="#ccffcc" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="0" name="linker" directionality="1" translationMW="333.30" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="1698" maxFusedRunOn="1698"><Segment range="964-978" color="#ccffcc" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  g<Notes>
<UUID>19b149aa-046e-47f6-8139-6eb6ba5ab4ba</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="8:45:35">2025.11.26</Created>
<LastModified UTC="8:46:0">2025.11.26</LastModified>
<CreatedBy>Triple Threat</CreatedBy>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
   ©<StrandColors><TopStrand><ColorRange range="0..6135" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..6135" colors="black"/></BottomStrand></StrandColors>  èý7zXZ  æÖ´F !   t/å£à#!§] Ë‡ØÎf‘ƒÊý{3Ôé·Ú(1v%f M*	mj÷)p80çÌ*iÚ	´NY]Qó“�úF7î&ƒÕ!Ò÷ÀnÉ;_x�Ó\À"iÒç"¬RMÌõ{åŽ—�íÚ‡.ÌãÛ¶—øÒçù¼M§ƒ^ÆÓÚ¹�28›¡Æ¼ª™ŠPSFðtÙ@Ö2‘¡'û]zëƒ-Œ`­¢�¢š~jÅíð8µ@BcÂm [S }ù­ÀŸ‹Ç$V5šªgZfëëJµðMKµZ†>·20·
Ï#§p>é¹�R‰ã°Â^bÏÔU±¬ãsNN¥³d_›@`P¿ýrÞ±`“¼ª|ÏîçñjJ†ó»0‘±%cLMumEæÍu|ôæÑ39¿ª°ÞÖ–¸×xêŠðhç{+�Z®¢¾·×ñó¡öÐåPÜ�µåIX?®B qc¼-ö´éÿ(«\7ø}œÈBqÊ]7,@æ>Û‰;,×4N˜å‹¯¢G‚ðnäÖëá€º~ŸðŠa¯½ÔÛH8!mO4ž­MxÜ›°¼o¬ÿí�ð\ÙšÚ ‰‰�P[¾¼ 8»L)Ö°9@èp¦ôrŸ1 žTÈQy§ÓÖUÑr>#ëÇS”°=?Ùc_¦=bÀ¨nÍ‰0ñ–Ä=˜�DÐÎYo­A…JÙýGúÎ°E(­çqxÜ #ž�³åŸcTóÏ•ˆÂV\¥_ÔRÇ{å1»xó~´ÌdM¢{¤ýP õ{ìIJ[Ìm¹ê‘
¾s·¾ŒÈ}ÂW.ÔÜaâÉ~2÷qÉ@¯s¥gÙàÈð<Íäïvà]ó›{NTb�ð’•dAâIHñˆÍÀ¼?Ny‰³â»D1“ˆb ÜaÜ«!e(³ÚÖ½ãŒÞ§‘)åJ¨–ž$RÖƒ¼ãæÏ§% ×ÊÑdŒè0»-Lgõ˜Äc>;þþ+êÝâý1ÄÝóMZ¶ì.æ–mDÇž)Aõ'~-ãº'V,áí”·œª0.
/b ™Ïò…í"ãIs*Œ²Ûj^JNË?ß ÊË,¿zL\b²É{‘‡Ç©T)ìßªçª�£¥R’Ç´<%¶ÿ ª00×…x˜nŒþ}ÒÈÁªÈ�‘Ý¡Òå¯ù€¶`³ýi=¹-â¼S×„ð�þ1ÞšLP®Rëðï'@º#�äZ®N]~‘Ë¤DC½IÓ¿��èáoˆPw˜Um,2K“¨¹ÿ~d÷Ájr>í&R’hC˜jIcÀ‡e‡.)Ñy†wcÖ�ñàeþŠM–˜Q}õñ�4‚>buY’]+kØ³—òÐV±YS›ò“d¼	„1ZoBþ€Õp›Åß†2 †F³0ÃQsÌ…¼œ�S¾qYLïò+rÓ­¥à�™øRŒ„ÚJbj9ý¯KÄ{2Ñ@åˆ¸¢ïrÞ€÷	ìŸÇjå­�A&ÓqÚÅxøiÜÍÚV`ZØjäûN«\íå9–þûžt«¿Äæ¶�µ�8W¡áñËu
ÔõD¡#í•8g#ÒÂàótL«0"ò¤Kä7·–s@ì¢nUØÍ>¡¹ÛQ´ôM²^ÒÇz’–$Ök)*žíg0�õÁ^gòb«6È×ïúˆÛ|^‹sí0uŠ¼¡ó’¾è¦ê‡6´ÿ‚€óÓDãú"Üš›òzâ›fïáÂ¦Ø‡Ò‘b†%Ñºâ6CsþX‰%iý YÎÌ’yŸÞ„~¿2Àë• z�Ý¡²± ˜K‘Y¶s ñ•ìŠ^We^q>|«Ÿ‘#õ¿Lã|ŽçPrhT�œ®cÁÅ!wh‚nC¼Ú
´QºŠE·Š£q]dã»¢C÷qÛ:MÕ 
¬Ù£aÖwÇ†}‡»îÜšò<­ÏÕœÒ*-}	ÐùâsLP>	š‚ dgIô“¡ÄìˆqÏš‡zlÅÚ`[Dga \Ë¨üP3¹'�à·>ð°ù¦¾¥�^Ä WÙ0v…o½¦öÄ>@r$ÛsG;Ð°@2÷XòGª-KrýLbÙ¬f˜ãaÆ™bkÇÑü�¸>Jò¯—z/='Ä
Î²•6êÿ`{U@™HÍ`÷°iûzµ�è ‘ò-á’·ÜéÕŒ-ZWdÓƒ	Ê–§@áâéÕØ±ìŽÃ/’íÏ0Ö²n�:‡&®>ƒUŒú8Ý·y>€àFž‘ÊÕKÚ77>‚-¡rc‘þ2ð4¦}ÁŠNÎlJ YÕlŽÙÙ8uäÓ³ÿ†sÈ�ÕÙµcC–6ÈÑÀWB{Í
õnæZÞ—¬‹_Ý�Ù¡¹�ªç…ÝßõNjÅ/ÉÌ»Lb2Fô'Œ¢Pð¤TuË£¹•ðŒ‡»‡ÝR6ã¶†ær[#KrÊ¤›…(Õâa¥¶ãˆp°ÏIM+´uCBB–F'Œ²v–P·ê	„—´)ë‰"íÎú(üŒüA»DLòKLêß!È�®®4l#ÇöÍ3�ûiÿlªÚÇ4•�a(NBq÷73hšÈü§N!ŠQCÎºØ›õùU|$Xà6¤ô;È˜L [±“‹(àÿÍx+,ÃhWD?‘Òw\¦_îdžnË�GŸÎa‹ìOÁ<Ÿ%îè¶EÜ:¨ô$“…Öµë*ÇÙo6Æ8*¨G?«�Ú&„Ë øúø±b®Â?ún³M€N†ÍNSÿà_ºâð›î‡tØYZE{Ù€ ‘„®ûÉUã‡¯=O¶›>J”xO”�ZhC,Ó¼�ƒqïuË‚´èÒl×f0Øì¢¯ÔRtì#<½æägv}H”~¯vr˜ôy{ÆþLc`6–ì›¡’ Ø®9+Óª„I¡Ñ%ï$¬AÙô_ÓöÎ™„Þ­zgMBN+XŒÄ›u4öfðÁA~lpÃ£cÈ 3S¤Õ~æÂ@q3ò˜|ºªÜuœyö$z"c=ë‚y*ÙtéˆËx	@-xG2‘Î   Ì¿¤¢ÍN‚ Ã¢F  	&Üš±Ägû    YZ   -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  *W<?xml version="1.0"?><Features nextValidID="21"><Feature recentID="0" name="NPM1" directionality="1" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="2564" maxFusedRunOn="2564"><Segment range="927-1808" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MEDSMDMDMSPLRPQNYLFGCELKADKDYHFKVDNDENEHQLSLRTVSLGAGAKDELHIVEAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHLVAVEEDAESEDEEEEDVKLLSISGKRSAPGGGSKVPQKKVKLAADEDDDDDDEEDDDEDDDDDDFDDEEAEEKAPVKKSIRDTPAKNAQKSNQNGKDSKPSSTPRSKGQESFKKQEKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVEAKFINYVKNCFRMTDQEAIQDLWQWRKSL"/></Q></Feature><Feature recentID="1" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="921-930" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="regulatory_class"><V predef="other"/></Q></Feature><Feature recentID="2" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4872-4888" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4848-4864" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="T7 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="863-881" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4941-4962" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment name="-10" range="4896-4902" color="#ffffff" type="standard"/><Segment range="4903-4920" color="#ffffff" type="standard"/><Segment name="-35" range="4921-4926" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6867-6971" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4678-4799" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3494-3629" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="615-818" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="bGH poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2602-2826" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bovine growth hormone polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="SV40 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3314-3643" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="235-614" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="f1 ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2872-3300" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5250-5835" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="EGFP" directionality="1" translationMW="26942.08" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="0" hitsStopCodon="1"><Segment range="1845-1847" color="#05fd14" type="standard" translated="1"/><Segment name="1a" range="1848-1850" color="#05fd14" type="standard" translated="1" translationNumberingStartsFrom="0"/><Segment range="1851-2564" color="#05fd14" type="standard" translated="1" translationNumberingStartsFrom="2"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mammalian codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;enhanced GFP&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="M,V,SKGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTLKFICTTGKLPVPWPTLVTTLTYGVQCFSRYPDHMKQHDFFKSAMPEGYVQERTIFFKDDGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNYNSHNVYIMADKQKNGIKVNFKIRHNIEDGSVQLADHYQQNTPIGDGPVLLPDNHYLSTQSALSKDPNEKRDHMVLLEFVTAAGITLGMDELYK*"/></Q></Feature><Feature recentID="17" name="NeoR/KanR" directionality="1" translationMW="29048.78" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="3710-4504" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MIEQDGLHAGSPAAWVERLFGYDWAQQTIGCSDAAVFRLSAQGRPVLFVKTDLSGALNELQDEAARLSWLATTGVPCAAVLDVVTEAGRDWLLLGEVPGQDLLSSHLAPAEKVSIMADAMRRLHTLDPATCPFDHQAKHRIERARTRMEAGLVDQDDLDEEHQGLAPAELFARLKARMPDGEDLVVTHGDACLPNIMVENGRFSGFIDCGRLGVADRYQDIALATRDIAEELGGEWADRFLVLYGIAAPDSQRIAFYRLLDEFF*"/></Q></Feature><Feature recentID="18" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="6797" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="6006-6797" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="6798-6866" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSIQHFRVALIPFFAAFCLPVFA,HPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW*"/></Q></Feature><Feature recentID="19" name="linker" directionality="1" translationMW="333.30" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="2564" maxFusedRunOn="2564"><Segment range="1815-1829" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="GGGGS"/></Q></Feature><Feature recentID="20" name="linker" directionality="1" translationMW="333.30" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="2564" maxFusedRunOn="2564"><Segment range="1830-1844" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="GGGGS"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  Ê<Notes>
<UUID>19b149aa-046e-47f6-8139-6eb6ba5ab4ba</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pCMV-NPM1(human)-EGFP-Neo</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Created UTC="8:45:35">2025.11.26</Created>
<LastModified UTC="8:4:28">2026.3.25</LastModified>
<CreatedBy>Triple Threat</CreatedBy>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  Y     K         
?????                                                                                                       ÿ d      HO ÿþ               E              ÿÿÿÿYô? P                                                                                                                                                              ©<StrandColors><TopStrand><ColorRange range="0..7001" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..7001" colors="black"/></BottomStrand></StrandColors>   3<?xml version="1.0"?><EnzymeVisibilities vals=""/>
   )<?xml version="1.0"?><CustomEnzymeSets/>
